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- Title
Preparation and characterization of pig plasma and platelet gelsolins.
- Authors
Weeds, A G; Gooch, J; Pope, B; Harris, H E
- Abstract
Pig plasma gelsolin has been prepared by a revised method involving poly(ethylene glycol) precipitation, chromatography on CM-cellulose and affinity chromatography on actin-Sepharose. Pig platelet gelsolin has been prepared by chromatography on DEAE-cellulose and actin-Sepharose. Partial chemical and proteolytic cleavage shows that the two proteins are closely related in their fragmentation patterns. The amino acid sequences are identical at the N-terminus of the platelet protein, but the plasma protein has an additional nine residues on the N-terminal side of the common sequence. Calcium binding studies show that the plasma protein has similar calcium binding properties to both macrophage and platelet gelsolins.
- Publication
European journal of biochemistry, 1986, Vol 161, Issue 1, p69
- ISSN
0014-2956
- Publication type
Journal Article
- DOI
10.1111/j.1432-1033.1986.tb10125.x