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- Title
The modification of the peptidyltransferase activity of 50-S ribosomal subunits, LiCl-split proteins and L16 ribosomal protein by pyridoxal phosphate.
- Authors
Baxter, R M; White, V T; Zahid, N D
- Abstract
Pyridoxal phosphate photoinactivates the peptidyltransferase activity of 50-S ribosomal subunits, LiCl split proteins and protein L16. Ethyromycin exhibits significant protection. These results, taken together with earlier reports, indicate the involvement of the single histidine of L16 in peptidyltransferase activity. The adjacent association in L16 of histidine and lysine indicates that pyridoxal phosphate should represent a selective inhibitor of peptidyltransferase activity.
- Publication
European journal of biochemistry, 1980, Vol 110, Issue 1, p161
- ISSN
0014-2956
- Publication type
Journal Article
- DOI
10.1111/j.1432-1033.1980.tb04851.x