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- Title
On the stereochemistry of activation of phenylalanine by phenylalanyl-tRNA synthetase from baker's yeast.
- Authors
von der Haar, F; Cramer, F; Eckstein, F; Stahl, K W
- Abstract
Because of its chiralic alpha-phosphorus atom adenosine 5'-O-(1-thiotriphosphate) (ATPalphaS) exists in two diastereomeric forms, arbitrarily named (A) and (B). For phenylalanyl-tRNA synthetase ATPalphaS (A) is a substrate whereas ATPalphaS (B) is neither a substrate nor an inhibitor. During the ATPalphaS (A)/PPi exchange reaction with phenylalanyl-tRNA synthetase the configuration at the alpha-phosphorus is retained. The mechanistic implications of these findings are discussed. Preliminary investigations with several other aminoacyl-tRNA synthetases show that the stereochemical requirement with respect to the alpha-phosphorus of ATP is not identical for all aminoacyl-tRNA synthetases.
- Publication
European journal of biochemistry, 1977, Vol 76, Issue 1, p263
- ISSN
0014-2956
- Publication type
Journal Article
- DOI
10.1111/j.1432-1033.1977.tb11591.x