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- Title
The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidance.
- Authors
Bercovitz, R S; Kelher, M R; Khan, S Y; Land, K J; Berry, T H; Silliman, C C
- Abstract
Plasma and platelet concentrates are disproportionately implicated in transfusion-related acute lung injury (TRALI). Platelet-derived pro-inflammatory mediators, including soluble CD40 ligand (sCD40L), accumulate during storage. We hypothesized that platelet contamination induces sCD40L generation that causes neutrophil [polymorphonuclear leucocyte (PMN)] priming and PMN-mediated cytotoxicity.
- Publication
Vox sanguinis, 2012, Vol 102, Issue 4, p345
- ISSN
1423-0410
- Publication type
Journal Article
- DOI
10.1111/j.1423-0410.2011.01559.x