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- Title
The efficacy of photochemical treatment with methylene blue and light for the reduction of Trypanosoma cruzi in infected plasma.
- Authors
Gironés, N; Bueno, J L; Carrión, J; Fresno, M; Castro, E
- Abstract
Chagas disease is a transfusion-transmitted infection. This study evaluates the efficacy of a methylene blue (MB) and light system for reducing the viability of Trypanosoma cruzi in plasma. MATERIALS AND METHODS Trypanosoma cruzi strains were spiked in plasma pools. Treatment arms included combined filtration, MB, light and freezing. Post-treatment parasite viability was assayed through in vitro cultures and in vivo inoculation in inducible nitric oxide synthase- and interferon-gamma-receptor-deficient mice.
- Publication
Vox sanguinis, 2006, Vol 91, Issue 4, p285
- ISSN
0042-9007
- Publication type
Journal Article
- DOI
10.1111/j.1423-0410.2006.00840.x