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- Title
Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial.
- Authors
Anand, Amit; Gunn, Abigail D; Barkay, Gavriel; Karne, Harish S; Nurnberger, John I; Mathew, Sanjay J; Ghosh, Samiran
- Abstract
Recent studies indicate that modulation of glutamate neurotransmission is associated with antidepressant response. Lamotrigine, an anticonvulsant which decreases presynaptic glutamate release, has been shown to be effective in the depressive phase of bipolar disorder (BD-D); however, only 40-50% of patients have a full response. This pilot study investigated whether memantine, a low-affinity N-methyl-D-aspartate (NMDA) receptor antagonist approved for Alzheimer's disease, can augment the effects of lamotrigine.
- Publication
Bipolar disorders, 2012, Vol 14, Issue 1, p64
- ISSN
1399-5618
- Publication type
Journal Article
- DOI
10.1111/j.1399-5618.2011.00971.x