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- Title
Lithium treatment attenuates muscarinic M(1) receptor dysfunction.
- Authors
Creson, Thomas K; Austin, Daniel R; Shaltiel, Galit; McCammon, Joseph; Wess, Jürgen; Manji, Husseini K; Chen, Guang
- Abstract
Altered muscarinic acetylcholine receptor levels and receptor-coupled signaling processes have been reported in mood disorders. M(1) , one of five muscarinic receptor subtypes, couples to the phospholipase C/protein kinase C and extracellular signal-regulated kinase (ERK) pathways. Mood stabilizers regulate these pathways. MicroRNAs (miRNAs) are small noncoding RNAs that suppress translation in a sequence-selective manner. Lithium downregulates several miRNAs, including let-7b and let-7c. One predicted target of let-7b and let-7c is the M(1) receptor. We hypothesized that miRNAs regulate M(1) receptor translation, and that disrupted M(1) expression leads to aberrant behaviors and disrupted downstream signaling pathways that are rescued by lithium treatment.
- Publication
Bipolar disorders, 2011, Vol 13, Issue 3, p238
- ISSN
1399-5618
- Publication type
Journal Article
- DOI
10.1111/j.1399-5618.2011.00915.x