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- Title
Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms.
- Authors
Mallinger, Alan G; Thase, Michael E; Haskett, Roger; Buttenfield, Joan; Luckenbaugh, David A; Frank, Ellen; Kupfer, David J; Manji, Husseini K
- Abstract
Attenuation of protein kinase C (PKC) is a mechanism common to both established (lithium, valproate) and some novel (tamoxifen) antimanic agents. Verapamil, although primarily known as a calcium channel blocker, also has PKC inhibitory activity. Verapamil has shown antimanic activity in some but not all studies. Therefore, we investigated verapamil, used alone or as an adjunctive treatment, in manic patients who did not respond to an initial adequate trial of lithium.
- Publication
Bipolar disorders, 2008, Vol 10, Issue 8, p856
- ISSN
1399-5618
- Publication type
Journal Article
- DOI
10.1111/j.1399-5618.2008.00636.x