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- Title
Homozygote inositol transporter knockout mice show a lithium-like phenotype.
- Authors
Bersudsky, Yuly; Shaldubina, Alona; Agam, Galila; Berry, Gerard T; Belmaker, Robert H
- Abstract
Lithium inhibits inositol monophosphatase and also reduces inositol transporter function. To determine if one or more of these mechanisms might underlie the behavioral effects of lithium, we studied inositol transporter knockout mice. We previously reported that heterozygous knockout mice with reduction of 15-37% in brain inositol had no abnormalities of pilocarpine sensitivity or antidepressant-like behavior in the Porsolt forced swim test. We now report on studies of homozygous inositol transporter knockout mice.
- Publication
Bipolar disorders, 2008, Vol 10, Issue 4, p453
- ISSN
1399-5618
- Publication type
Journal Article
- DOI
10.1111/j.1399-5618.2007.00546.x