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- Title
Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings.
- Authors
Silverstone, Peter H; McGrath, Brent M; Kim, Hyeonjin
- Abstract
Myo-inositol is an important component of the phosphatidylinositol second messenger system (PI-cycle). Alterations in PI-cycle activity have been suggested to be involved in the pathophysiology and/or treatment of bipolar disorder. More specifically, lithium has been suggested to act primarily by lowering myo-inositol concentrations, the so-called inositol-depletion hypothesis. myo-Inositol concentrations can be measured in vivo with magnetic resonance spectroscopy (MRS).
- Publication
Bipolar disorders, 2005, Vol 7, Issue 1, p1
- ISSN
1398-5647
- Publication type
Journal Article
- DOI
10.1111/j.1399-5618.2004.00174.x