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- Title
Predicting islet yield in pediatric patients undergoing pancreatectomy and autoislet transplantation for chronic pancreatitis.
- Authors
Bellin, Melena D; Blondet, Juan J; Beilman, Gregory J; Dunn, Ty B; Balamurugan, A N; Thomas, William; Sutherland, David E R; Moran, Antoinette
- Abstract
Chronic pancreatitis (CP) in children is associated with significant morbidity and can lead to narcotic dependence. Total pancreatectomy (TP) may be indicated in refractory CP to relieve pain; simultaneous islet autotransplant (IAT) may prevent postsurgical diabetes. About half of pediatric patients are insulin independent 1 yr after IAT. Insulin independence correlates best with the number of islets available for transplantation (islet yield). Currently there is no known method to predict islet yield in a given patient. We assessed the ability of preoperative metabolic tests to predict islet yields in 10 children undergoing TP/IAT.
- Publication
Pediatric diabetes, 2010, Vol 11, Issue 4, p227
- ISSN
1399-5448
- Publication type
Journal Article
- DOI
10.1111/j.1399-5448.2009.00575.x