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- Title
Creation of a prevascularized site for cell transplantation in rats.
- Authors
Stiegler, Philipp; Matzi, Veronika; Pierer, Eve; Hauser, Oliver; Schaffellner, Silvia; Renner, Heiko; Greilberger, Joachim; Aigner, Reingard; Maier, Alfred; Lackner, Carolin; Iberer, Florian; Smolle-Jüttner, Freyja-Maria; Tscheliessnigg, Karlheinz; Stadlbauer, Vanessa
- Abstract
Transplanted cells, especially islet cells, are likely to become apoptotic due to local hypoxia leading to graft dysfunction. Isolated pancreatic islet cells depend on the diffusion of oxygen from the surrounding tissue; therefore, access to sufficient oxygen supply is beneficial, particularly when microcapsules are used for immunoisolation in xenotransplantation. The aim of this study was to create a prevascularized site for cell transplantation in rats and test its effectiveness with microencapsulated HEK293 cells.
- Publication
Xenotransplantation, 2010, Vol 17, Issue 5, p379
- ISSN
1399-3089
- Publication type
Journal Article
- DOI
10.1111/j.1399-3089.2010.00606.x