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- Title
Occurrence of specific humoral non-responsiveness to swine antigens following administration of GalT-KO bone marrow to baboons.
- Authors
Griesemer, Adam; Liang, Fan; Hirakata, Atsushi; Hirsh, Erica; Lo, Diana; Okumi, Masayoshi; Sykes, Megan; Yamada, Kazuhiko; Huang, Christene A; Sachs, David H
- Abstract
Hematopoietic chimerism induces transplantation tolerance across allogeneic and xenogeneic barriers, but has been difficult to achieve in the pig-to-primate model. We have now utilized swine with knockout of the gene coding for alpha-1,3-galactosyltransferase (GalT-KO pigs) as bone marrow donors in an attempt to achieve chimerism and tolerance by avoiding the effects of natural antibodies to Gal determinants on pig hematopoietic cells.
- Publication
Xenotransplantation, 2010, Vol 17, Issue 4, p300
- ISSN
1399-3089
- Publication type
Journal Article
- DOI
10.1111/j.1399-3089.2010.00600.x