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- Title
Propylthiouracil-associated liver failure presenting as probable autoimmune hepatitis in a child with Graves' disease.
- Authors
Sipe, Walter E B; Su, Maureen; Posselt, Andrew; Kim, Grace E; Quiros, Jose Antonio; Rosenthal, Philip
- Abstract
This case describes a young girl with Graves' disease, who presented with fulminant hepatic failure 9 months into propylthiouracil (PTU) therapy. Her clinical presentation was consistent with 'probable autoimmune hepatitis,' as defined by the International Autoimmune Hepatitis Group scoring system. Despite discontinuation of PTU and high-dose steroid therapy, she required liver transplantation. Subsequent pathology could not definitively rule out autoimmune hepatitis. PTU is an important cause of drug-related liver failure in children, and clinicians should be mindful that it is frequently used in patients who already have an underlying risk of autoimmune liver disease.
- Publication
Pediatric transplantation, 2006, Vol 10, Issue 4, p525
- ISSN
1397-3142
- Publication type
Journal Article
- DOI
10.1111/j.1399-3046.2006.00487.x