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- Title
The vitamin D slant on allergy.
- Authors
Wjst, Matthias
- Abstract
Oral vitamin D supplementation has been introduced into modern medicine to prevent rickets without the knowledge that this may have profound immunological consequences. The main vitamin D metabolite calcitriol suppresses dendritic cell maturation and consecutive Th(1) cell development, which has independently described as a key mechanism of allergy development. Animal studies and epidemiological surveys now provide a first link of early vitamin D supplementation and later allergy where several vitamin D regulated genes seem to be involved. A randomized clinical trial of vitamin D supplementation could be a further step to follow up the vitamin hypothesis.
- Publication
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2006, Vol 17, Issue 7, p477
- ISSN
0905-6157
- Publication type
Research
- DOI
10.1111/j.1399-3038.2006.00456.x