We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China.
- Authors
Yang, G; Deng, Y-J; Hu, S-N; Wu, D-Y; Li, S-B; Zhu, J; Zhu, B-F; Liu, Y
- Abstract
DNA typing for human leukocyte antigen (HLA)-A, -B and -DRB1 was performed using polymerase chain reaction-sequence-based typing method on 618 randomly selected healthy individuals of the Han population in Northern China. Allele frequencies and haplotypes were statistically analyzed. A total of 84 HLA-A alleles, 143 B alleles, and 122 DRB1 alleles were detected, and 853 A-B-DRB1 haplotypes, 473 A-B haplotypes, and 551 B-DRB1 haplotypes were statistically inferred. Statistical analysis of three-locus haplotypes showed that A*0207-B*4601-DRB1*0901 (3.06%) was the most predominant. Gene frequencies and haplotypic associations within HLA-A, -B, and -DRB1 loci were determined at a high-resolution (four digit) allelic level and should provide useful information in anthropology, bone marrow donor registry, legal medicine, and disease association studies.
- Publication
Tissue antigens, 2006, Vol 67, Issue 2, p146
- ISSN
0001-2815
- Publication type
Journal Article
- DOI
10.1111/j.1399-0039.2006.00529.x