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- Title
Calcineurin inhibitor-sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity.
- Authors
Flechner, Stuart M; Kobashigawa, Jon; Klintmalm, Goran
- Abstract
The calcineurin inhibitors (CNIs), cyclosporine and tacrolimus, have had a revolutionary effect on the overall success of renal transplantation through reduction in early immunologic injury and acute rejection rates. However, the CNIs have a significant adverse impact on renal function and cardiovascular disease, and extended long-term graft survival has not been achieved. The recognition of these effects sparked interest in CNI-sparing strategies. Strategies to limit CNI exposure include CNI minimization, avoidance, and withdrawal. We sought to review the impact of CNI-sparing strategies in kidney, liver, and heart transplantation.
- Publication
Clinical transplantation, 2008, Vol 22, Issue 1, p1
- ISSN
1399-0012
- Publication type
Journal Article
- DOI
10.1111/j.1399-0012.2007.00739.x