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- Title
The human phenotype ontology.
- Authors
Robinson, P N; Mundlos, S
- Abstract
A standardized, controlled vocabulary allows phenotypic information to be described in an unambiguous fashion in medical publications and databases. The Human Phenotype Ontology (HPO) is being developed in an effort to provide such a vocabulary. The use of an ontology to capture phenotypic information allows the use of computational algorithms that exploit semantic similarity between related phenotypic abnormalities to define phenotypic similarity metrics, which can be used to perform database searches for clinical diagnostics or as a basis for incorporating the human phenome into large-scale computational analysis of gene expression patterns and other cellular phenomena associated with human disease. The HPO is freely available at http://www.human-phenotype-ontology.org.
- Publication
Clinical genetics, 2010, Vol 77, Issue 6, p525
- ISSN
1399-0004
- Publication type
Journal Article
- DOI
10.1111/j.1399-0004.2010.01436.x