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- Title
The ZIC gene family in development and disease.
- Authors
Grinberg, I; Millen, K J
- Abstract
The human ZIC gene family is comprised of five members encoding zinc-finger transcription factors, which are the vertebrate homologs of the Drosophila odd-paired gene. Mutations in ZIC genes in humans have recently been implicated in a wide variety of congenital malformations, including Dandy-Walker malformation, holoprosencephaly, neural tube defects, and heterotaxy. Mutant analysis of these genes in mice has underscored the conserved developmental roles of these genes. Further, this analysis has begun to elucidate the molecular and developmental mechanisms underlying these important birth defects.
- Publication
Clinical genetics, 2005, Vol 67, Issue 4, p290
- ISSN
0009-9163
- Publication type
Journal Article
- DOI
10.1111/j.1399-0004.2005.00418.x