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- Title
Oral allergy syndrome: the effect of astemizole.
- Authors
Bindslev-Jensen, C; Vibits, A; Stahl Skov, P; Weeke, B
- Abstract
The effect of treatment with astemizole (Hismanal) on symptoms elicited by ingestion of hazelnuts in birch pollen-allergic patients (the oral allergy syndrome) was investigated. Thirty patients with a well-documented allergy to silver birch, experiencing symptoms when ingesting hazelnuts, were included in the study. All had a positive skin prick test (SPT) to birch, whereas 29 and 27, respectively, showed a positive RAST and basophil histamine release test (HR) to birch. In contrast, only 15 patients had a positive SPT to hazelnut, 13 had a positive RAST, whereas 24 had a positive HR. After two oral provocations with hazelnuts the patients were randomized to receive either 10 mg of astemizole or placebo daily for 2 weeks in a double blind protocol followed by two oral provocations. Treatment with astemizole significantly reduced the symptoms compared with placebo (P = 0.004); however, without completely abolishing the symptoms.
- Publication
Allergy, 1991, Vol 46, Issue 8, p610
- ISSN
0105-4538
- Publication type
Journal Article
- DOI
10.1111/j.1398-9995.1991.tb00631.x