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- Title
Inhalation of racemic epinephrine in children with asthma. Dose-response relation and comparison with salbutamol.
- Authors
Kjellman, B; Tollig, H; Wettrell, G
- Abstract
In this study the effects of nebulized racemic epinephrine (Micronephrine) were investigated in children with asthma. The drug was inhaled by a compressor nebulizer with a plastic mask. In the first part of the study it is shown that nebulized Micronephrine has a dose-dependent bronchodilatory effect. In the second part the effect is compared with that of nebulized salbutamol in 10 children (7-16 years of age) with bronchial asthma. The highest dose used in the dose-response trials (=0.9 mg Micronephrine/kg body-weight) was compared with 0.15 mg salbutamol/kg body-weight, which is the dose commonly used in Sweden. There was no significant difference between the drugs as regards increase of forced expiratory volume in 1 sec or duration of the increase. There was a small but significant increase in systolic blood pressure, measured 5 min after the inhalation of Micronephrine but no significant change in diastolic pressure or heart rate. Four children complained of temporary sore throat after the inhalation.
- Publication
Allergy, 1980, Vol 35, Issue 7, p605
- ISSN
0105-4538
- Publication type
Journal Article
- DOI
10.1111/j.1398-9995.1980.tb01811.x