We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Vitamin E added silicone gel sheets for treatment of hypertrophic scars and keloids.
- Authors
Palmieri, B; Gozzi, G; Palmieri, G
- Abstract
Trauma of various origins can induce a connective tissue disorder that leads to keloids. This condition has yet not been clearly distinguished from scars and hypertrophic scars. Only electronmicroscopic and biochemical data can help to do this. Among some more or less therapeutic approaches, the use of silicon (polydimethylsiloxane) plates, wrapped on the keloid surface, has been reported effective by some authors. These authors also demonstrated that it is not the mechanical pressure that is the mechanism of action, but a direct action on fibroblasts and a hyperhydration of subcutaneous tissue. The authors of this study conceived that the silicon plate may be able to improve the transdermal penetration of a compound such as vitamin E. This vitamin is capable of preserving some important morphologic and functional features of biological membranes by means of its phytilside chain of the molecule acting as a stabilizer of lysosomal membranes.
- Publication
International journal of dermatology, 1995, Vol 34, Issue 7, p506
- ISSN
0011-9059
- Publication type
Journal Article
- DOI
10.1111/j.1365-4362.1995.tb00628.x