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- Title
IgE Anti- Borrelia burgdorferi Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8<sup>+</sup>CD60<sup>+</sup> T Cells in Children with Lyme Disease.
- Authors
Bluth, M. H.; Robin, J.; Ruditsky, M.; Norowitz, K. B.; Chice, S.; Pytlak, E.; Nowakowski, M.; Durkin, H. G.; Smith-Norowitz, T. A.
- Abstract
Immunoglobulin (Ig) E may provide immunity against Borrelia burgdorferi infection (Lyme disease) in children which lasts throughout adulthood. We investigated the presence and persistence of IgE anti- B. burgdorferi antibodies (Abs) in paediatric patients infected with Lyme disease over time. Serum immunoglobulin levels, presence of IgG and IgE anti- B. burgdorferi components, and distributions of blood T, B and natural killer lymphocyte subsets were studied in B. burgdorferi-infected and -uninfected children (nephelometry, UniCAP Total IgE Fluoroenzymeimmunoassay, Western blot, flow cytometry). Total serum IgM, IgG, IgE and IgA levels, and distributions of blood lymphocytes (CD4+, CD8+, CD19+) of both groups, excluding CD8+CD60+ T cells, were within normal ranges. However, infected, but not uninfected children made IgG anti- B. burgdorferi proteins p18, p31, p34, p41, p45, but not IgG anti-p60, and IgE anti- B. burgdorferi proteins p31, p34, p41, p45, p60, but not IgE anti-p18. These proteins were also detected in an infected child 1 year post-infection. Interestingly, CD8+CD60+ T-cell numbers were significantly increased (fourfold) in infected, compared with uninfected, patients ( P = 0.001). These results demonstrate that specific IgE anti- B. burgdorferi Abs are generated and persist in children with Lyme disease and that CD8+CD60+ T cells may play an important role in these responses.
- Publication
Scandinavian Journal of Immunology, 2007, Vol 65, Issue 4, p376
- ISSN
0300-9475
- Publication type
Academic Journal
- DOI
10.1111/j.1365-3083.2007.01904.x