We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances.
- Authors
Leng, J; Butcher, B A; Denkers, E Y
- Abstract
The opportunistic protozoan parasite Toxoplasma gondii is well known as a strong inducer of cell-mediated immunity, largely as a result of proinflammatory cytokine induction during in vivo infection. Yet, during intracellular infection the parasite suppresses signal transduction pathways leading to these proinflammatory responses. The opposing responses are likely to reflect the parasite's need to stimulate immunity allowing host survival and parasite persistence, and at the same time avoiding excessive responses that could result in parasite elimination and host immunopathology. This Review summarizes past and present investigations into the effects of Toxoplasma on host cell signal transduction. These studies reveal insight into the profound suppression of proinflammatory cytokine responses that occurs when the parasite infects macrophages and other cells of innate immunity.
- Publication
Parasite immunology, 2009, Vol 31, Issue 12, p717
- ISSN
1365-3024
- Publication type
Journal Article
- DOI
10.1111/j.1365-3024.2009.01122.x