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- Title
Limited expression of heparan sulphate proteoglycans associated with Aβ deposits in the APPswe/PS1dE9 mouse model for Alzheimer's disease.
- Authors
Timmer, N M; Herbert, M K; Kleinovink, J W; Kiliaan, A J; De Waal, R M W; Verbeek, M M
- Abstract
Alzheimer's disease (AD) is characterized by deposition of the amyloid beta (Aβ) peptide in brain parenchyma and vasculature. Several proteins co-deposit with Aβ, including heparan sulphate proteoglycans (HSPG). HSPG have been suggested to contribute to Aβ aggregation and deposition, and may influence plaque formation and persistence by stimulating Aβ fibrillization and by protecting Aβ against degradation. Mouse models for AD, expressing the human amyloid precursor protein (APP), produce Aβ deposits similar to humans. These models may be used to study disease pathology and to develop new therapeutic interventions. We aimed to investigate whether co-deposition of HSPG in AD brains can be replicated in the APPswe/PS1dE9 mouse model for AD and if a temporal association of HSPG with Aβ exists.
- Publication
Neuropathology and applied neurobiology, 2010, Vol 36, Issue 6, p478
- ISSN
1365-2990
- Publication type
Journal Article
- DOI
10.1111/j.1365-2990.2010.01091.x