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- Title
The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?
- Authors
Grinberg, L T; Rüb, U; Ferretti, R E L; Nitrini, R; Farfel, J M; Polichiso, L; Gierga, K; Jacob-Filho, W; Heinsen, H; Brazilian Brain Bank Study Group
- Abstract
Alzheimer's disease (AD) is a progressive and irreversible disease. There is strong evidence that the progression of the phospho-tau neurofibrillary cytoskeletal changes, rather than the beta-amyloid burden, is crucial in determining the severity of the dementia in AD. The Braak and Braak staging system (BB) focuses mainly on the cortical cytoskeletal pathology and classifies this progressive pathology into six stages, spreading from the transentorhinal region to primary cortices. Although it is reported elsewhere that the midbrain's dorsal raphe nucleus (DR), which is connected with those areas of the cerebral cortex undergoing early changes during BB I and II, exhibits AD-related cytoskeletal pathology, this nucleus has not been considered by the BB.
- Publication
Neuropathology and applied neurobiology, 2009, Vol 35, Issue 4, p406
- ISSN
1365-2990
- Publication type
Journal Article
- DOI
10.1111/j.1365-2990.2009.00997.x