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- Title
Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle.
- Authors
Chu, J; Miller, C T; Kislitsyna, K; Laine, G A; Stewart, R H; Cox, C S; Uray, K S
- Abstract
Intestinal edema development after trauma resuscitation inhibits intestinal motility which results in ileus, preventing enteral feeding and compromising patient outcome. We have shown previously that decreased intestinal motility is associated with decreased smooth muscle myosin light chain (MLC) phosphorylation. The purpose of the present study was to investigate the mechanism of edema-induced decreases in MLC in a rodent model of intestinal edema.
- Publication
Neurogastroenterology and motility, 2012, Vol 24, Issue 3, p257
- ISSN
1365-2982
- Publication type
Journal Article
- DOI
10.1111/j.1365-2982.2011.01855.x