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- Title
Lesioning of TRPV1 expressing primary afferent neurons prevents PAR-2 induced motility, but not mechanical hypersensitivity in the rat colon.
- Authors
Suckow, S K; Anderson, E M; Caudle, R M
- Abstract
Proteinase activated receptor 2 (PAR-2) is expressed by many neurons in the colon, including primary afferent neurons that co-express transient receptor potential vanilloid 1 (TRPV1). Activation of PAR-2 receptors was previously found to enhance colonic motility, increase secretion and produce hypersensitivity to mechanical stimuli. This study examined the functional role of TRPV1/PAR-2 expressing neurons that innervate the colon by lesioning TRPV1 bearing neurons with the highly selective and potent TRPV1 agonist resiniferatoxin.
- Publication
Neurogastroenterology and motility, 2012, Vol 24, Issue 3, pe125
- ISSN
1365-2982
- Publication type
Journal Article
- DOI
10.1111/j.1365-2982.2011.01848.x