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- Title
Genomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization.
- Authors
Wade, Joseph T; Struhl, Kevin; Busby, Stephen J W; Grainger, David C
- Abstract
Chromatin immunoprecipitation (ChIP) is a powerful method to measure protein-DNA interactions in vivo, and it can be applied on a genomic scale with microarray technology (ChIP-chip). ChIP-chip has been used extensively to map DNA-protein interactions across eukaryotic chromosomes. Here we review recent applications of ChIP-chip to the study of bacteria, which provide important and unexpected insights into transcription and chromosome organization.
- Publication
Molecular microbiology, 2007, Vol 65, Issue 1, p21
- ISSN
0950-382X
- Publication type
Journal Article
- DOI
10.1111/j.1365-2958.2007.05781.x