Works matching AU Brown, Eric D.

Results: 49

Creative targeting of the Gram‐negative outer membrane in antibiotic discovery.

Published in:

Annals of the New York Academy of Sciences, 2020, v. 1459, n. 1, p. 69, doi. 10.1111/nyas.14280

By:

MacNair, Craig R.;
Tsai, Caressa N.;
Brown, Eric D.

Publication type:

Article

Unconventional screening approaches for antibiotic discovery.

Published in:

Annals of the New York Academy of Sciences, 2015, v. 1354, n. 1, p. 54, doi. 10.1111/nyas.12803

By:

Farha, Maya A.;
Brown, Eric D.

Publication type:

Article

Inside Cover: A Dual Reporter System for Detecting RNA Interactions in Bacterial Cells (ChemBioChem 18/2014).

Published in:

ChemBioChem, 2014, v. 15, n. 18, p. 2630, doi. 10.1002/cbic.201490063

By:

Kuryllo, Kacper;
Jahanshahi, Shahrzad;
Zhu, Weijia;
Brown, Eric D.;
Li, Yingfu

Publication type:

Article

A Dual Reporter System for Detecting RNA Interactions in Bacterial Cells.

Published in:

ChemBioChem, 2014, v. 15, n. 18, p. 2703, doi. 10.1002/cbic.201402322

By:

Kuryllo, Kacper;
Jahanshahi, Shahrzad;
Zhu, Weijia;
Brown, Eric D.;
Li, Yingfu

Publication type:

Article

Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-58202-w

By:

Li, Franco K. K.;
Peters, Shaun C.;
Worrall, Liam J.;
Sun, Tianjun;
Hu, Jinhong;
Vuckovic, Marija;
Farha, Maya;
Palacios, Armando;
Caveney, Nathanael A.;
Brown, Eric D.;
Strynadka, Natalie C. J.

Publication type:

Article

The worm turns for antimicrobial discovery.

Published in:

Nature Biotechnology, 2006, v. 24, n. 9, p. 1098, doi. 10.1038/nbt0906-1098

By:

Bhavsar, Amit P.;
Brown, Eric D.

Publication type:

Article

Broadened glycosylation patterning of heterologously produced erythromycin.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 11, p. 2771, doi. 10.1002/bit.26735

By:

Fang, Lei;
Zhang, Guojian;
El‐Halfawy, Omar;
Simon, Max;
Brown, Eric D.;
Pfeifer, Blaine A.

Publication type:

Article

Drug discovery: Not as fab as we thought.

Published in:

Nature, 2009, v. 458, n. 7234, p. 39, doi. 10.1038/458039a

By:

Zlitni, Soumaya;
Brown, Eric D.

Publication type:

Article

Microbiology: Antibiotic stops ‘ping-pong’ match.

Published in:

Nature, 2006, v. 441, n. 7091, p. 293, doi. 10.1038/441293a

By:

Brown, Eric D.

Publication type:

Article

Cell wall assembly in Bacillus subtilis: how spirals and spaces challenge paradigms.

Published in:

Molecular Microbiology, 2006, v. 60, n. 5, p. 1077, doi. 10.1111/j.1365-2958.2006.05169.x

By:

Bhavsar, Amit P.;
Brown, Eric D.

Publication type:

Article

Silent but deadly: IS200 promotes pathogenicity in Salmonella Typhimurium.

Published in:

RNA Biology, 2018, v. 15, n. 2, p. 176, doi. 10.1080/15476286.2017.1403001

By:

Ellis, Michael J.;
Carfrae, Lindsey A.;
Macnair, Craig R.;
Trussler, Ryan S.;
Brown, Eric D.;
Haniford, David B.

Publication type:

Article

Tomato Peroxidase: Rapid Isolation and Partial Characterization.

Published in:

Journal of Food Science (Wiley-Blackwell), 1989, v. 54, n. 5, p. 1269, doi. 10.1111/j.1365-2621.1989.tb05971.x

By:

MARANGONI, ALEJANDRO G.;
BROWN, ERIC D.;
STANLEY, DAVID W.;
YADA, RICKEY Y.

Publication type:

Article

Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 1, p. 43, doi. 10.1038/ja.2013.100

By:

Sewell, Edward WC;
Brown, Eric D

Publication type:

Article

A comprehensive guide to dynamic analysis of microbial gene expression using the 3D-printed PFIbox and a fluorescent reporter library.

Published in:

Nature Protocols, 2020, v. 15, n. 2, p. 575, doi. 10.1038/s41596-019-0257-0

By:

French, Shawn;
Guo, Amelia Bing Ya;
Brown, Eric D.

Publication type:

Article

Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria.

Published in:

PLoS Pathogens, 2019, v. 15, n. 5, p. 1, doi. 10.1371/journal.ppat.1007723

By:

Kattke, Michele D.;
Gosschalk, Jason E.;
Martinez, Orlando E.;
Kumar, Garima;
Gale, Robert T.;
Cascio, Duilio;
Sawaya, Michael R.;
Philips, Martin;
Brown, Eric D.;
Clubb, Robert T.

Publication type:

Article

Chemical modulators of ribosome biogenesis as biological probes.

Published in:

Nature Chemical Biology, 2015, v. 11, n. 12, p. 924, doi. 10.1038/nchembio.1957

By:

Stokes, Jonathan M;
Brown, Eric D

Publication type:

Article

Food for thought: Opportunities to target carbon metabolism in antibacterial drug discovery.

Published in:

Annals of the New York Academy of Sciences, 2023, v. 1524, n. 1, p. 51, doi. 10.1111/nyas.14991

By:

Tong, Madeline;
Brown, Eric D.

Publication type:

Article

Phage–antibiotic combinations: a promising approach to constrain resistance evolution in bacteria.

Published in:

Annals of the New York Academy of Sciences, 2021, v. 1496, n. 1, p. 23, doi. 10.1111/nyas.14533

By:

North, Olesia I.;
Brown, Eric D.

Publication type:

Article

Identification of a Toxic Peptide through Bidirectional Expression of Small RNAs.

Published in:

ChemBioChem, 2009, v. 10, n. 2, p. 238, doi. 10.1002/cbic.200800591

By:

Mok, Wendy W. K.;
Navani, Naveen K.;
Barker, Courtney;
Sawchyn, Bobbijo L.;
Gu, Jimmy;
Pathania, Ranjana;
Zhu, Rebecca D.;
Brown, Eric D.;
Li, Yingfu

Publication type:

Article

Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry.

Published in:

ChemBioChem, 2008, v. 9, n. 16, p. 2650, doi. 10.1002/cbic.200800304

By:

Tropak, Michael B.;
Kornhaber, Gregory J.;
Rigat, Brigitte A.;
Maegawa, Gustavo H.;
Buttner, Justin D.;
Blanchard, Jan E.;
Murphy, Cecilia;
Tuske, Steven J.;
Coales, Stephen J.;
Hamuro, Yoshitomo;
Brown, Eric D.;
Mahuran, Don J.

Publication type:

Article

Cover Picture: Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry (ChemBioChem 16/2008).

Published in:

ChemBioChem, 2008, v. 9, n. 16, p. 2549, doi. 10.1002/cbic.200890061

By:

Tropak, Michael B.;
Kornhaber, Gregory J.;
Rigat, Brigitte A.;
Maegawa, Gustavo H.;
Buttner, Justin D.;
Blanchard, Jan E.;
Murphy, Cecilia;
Tuske, Steven J.;
Coales, Stephen J.;
Hamuro, Yoshitomo;
Brown, Eric D.;
Mahuran, Don J.

Publication type:

Article

A FACS-Based Approach to Engineering Artificial Riboswitches.

Published in:

ChemBioChem, 2008, v. 9, n. 12, p. 1906, doi. 10.1002/cbic.200700713

By:

Fowler, Casey C.;
Brown, Eric D.;
Li, Yingfu

Publication type:

Article

The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III.

Published in:

ChemBioChem, 2008, v. 9, n. 9, p. 1385, doi. 10.1002/cbic.200800026

By:

Pereira, Mark P.;
Schertzer, Jefferey W.;
D'Elia, Michael A.;
Koteva, Kalinka P.;
Hughes, Donald W.;
Wright, Gerard D.;
Brown, Eric D.

Publication type:

Article

Isolation of DNA Aptamers for CDP-Ribitol Synthase, and Characterization of Their Inhibitory and Structural Properties.

Published in:

ChemBioChem, 2007, v. 8, n. 17, p. 2052, doi. 10.1002/cbic.200700257

By:

Allali-Hassani, Abdellah;
Pereira, Mark P.;
Navani, Naveen K.;
Brown, Eric D.;
Li, Yingfu

Publication type:

Article

A High-throughput Pharmacoviral Approach Identifies Novel Oncolytic Virus Sensitizers.

Published in:

Molecular Therapy, 2010, v. 18, n. 6, p. 1123, doi. 10.1038/mt.2010.67

By:

Diallo, Jean-Simon;
Le Boeuf, Fabrice;
Lai, Frances;
Cox, Julie;
Vaha-Koskela, Markus;
Abdelbary, Hesham;
MacTavish, Heather;
Waite, Katherine;
Falls, Theresa;
Wang, Jenny;
Brown, Ryan;
Blanchard, Jan E.;
Brown, Eric D.;
Kirn, David H.;
Hiscott, John;
Atkins, Harry;
Lichty, Brian D.;
Bell, John C.

Publication type:

Article

PhoR autokinase activity is controlled by an intermediate in wall teichoic acid metabolism that is sensed by the intracellular PAS domain during the PhoPR-mediated phosphate limitation response of B acillus subtilis.

Published in:

Molecular Microbiology, 2014, v. 94, n. 6, p. 1242, doi. 10.1111/mmi.12833

By:

Botella, Eric;
Devine, Susanne Krogh;
Hubner, Sebastian;
Salzberg, Letal I.;
Gale, Robert T.;
Brown, Eric D.;
Link, Hannes;
Sauer, Uwe;
Codée, Jeroen D.;
Noone, David;
Devine, Kevin M.

Publication type:

Article

Ribosome biogenesis; the KsgA protein throws a methyl-mediated switch in ribosome assembly.

Published in:

Molecular Microbiology, 2008, v. 70, n. 5, p. 1051, doi. 10.1111/j.1365-2958.2008.06484.x

By:

Mangat, Chand S.;
Brown, Eric D.

Publication type:

Article

Small-Molecule Screening Made Simple for a Difficult Target with a Signaling Nucleic Acid Aptamer that Reports on Deaminase Activity.

Published in:

Angewandte Chemie International Edition, 2006, v. 45, n. 34, p. 5648, doi. 10.1002/anie.200601695

By:

Elowe, Nadine H.;
Nutiu, Razvan;
Allali-Hassani, Abdellah;
Cechetto, Jonathan D.;
Hughes, Donald W.;
Li, Yingfu;
Brown, Eric D.

Publication type:

Article

Comment: Canadian Chemical Biology Network: biochemistry back to the future / Commentaire : Réseau canadien de biologie chimique: la biochimie de retour vers le futur.

Published in:

Biochemistry & Cell Biology, 2008, v. 86, n. 2, p. ix, doi. 10.1139/o08-903

By:

Brown, Eric D.;
Thomas, David Y.

Publication type:

Article

Small and lethal: searching for new antibacterial compounds with novel modes of action.

Published in:

Biochemistry & Cell Biology, 2008, v. 86, n. 2, p. 111, doi. 10.1139/O08-011

By:

Pathania, Ranjana;
Brown, Eric D.

Publication type:

Article

Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology.

Published in:

Biochemistry & Cell Biology, 2005, v. 83, n. 6, p. 738, doi. 10.1139/O05-162

By:

Brown, Eric D.

Publication type:

Article

Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-02875-z

By:

MacNair, Craig R.;
Stokes, Jonathan M.;
Carfrae, Lindsey A.;
Fiebig-Comyn, Aline A.;
Coombes, Brian K.;
Mulvey, Michael R.;
Brown, Eric D.

Publication type:

Article

Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 5, p. 582, doi. 10.1038/nsmb.1819

By:

Lovering, Andrew L.;
Lin, Leo Y.-C.;
Sewell, Edward W.;
Spreter, Thomas;
Brown, Eric D.;
Strynadka, Natalie C. J.

Publication type:

Article

Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.

Published in:

Nature, 1999, v. 397, n. 6715, p. 176, doi. 10.1038/16495

By:

Alm, Richard A.;
Ling, Lo-See L.;
Moir, Donald T.;
King, Benjamin L.;
Brown, Eric D.;
Doig, Peter C.;
Smith, Douglas R.;
Noonan, Brian;
Guild, Brayson C.;
deJonge, Boudewijn L.;
Carmel, Gilles;
Tummino, Peter J.;
Caruso, Anthony;
Uria-Nickelsen, Maria;
Mills, Debra M.;
Ives, Cameron;
Gibson, Rene;
Merberg, David;
Mills, Scott D.;
Qin Jiang

Publication type:

Article

A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepacia.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0128587

By:

Selin, Carrie;
Stietz, Maria S.;
Blanchard, Jan E.;
Gehrke, Sebastian S.;
Bernard, Sylvain;
Hall, Dennis G.;
Brown, Eric D.;
Cardona, Silvia T.

Publication type:

Article

Is the GAIN Act a turning point in new antibiotic discovery?<sup>1</sup>.

Published in:

Canadian Journal of Microbiology, 2013, v. 59, n. 3, p. 153, doi. 10.1139/cjm-2013-0089

By:

Brown, Eric D.

Publication type:

Article

Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics.

Published in:

PLoS Genetics, 2023, v. 19, n. 11, p. 1, doi. 10.1371/journal.pgen.1011013

By:

Yaeger, Luke N.;
French, Shawn;
Brown, Eric D.;
Côté, Jean Philippe;
Burrows, Lori L.

Publication type:

Article

Forty Years of Resistance in TA Education.

Published in:

WPA: Writing Program Administration - Journal of the Council of Writing Program Administrators, 2019, v. 42, n. 3, p. 65

By:

Brown, Eric D.;
Conner, Savanna G.

Publication type:

Article

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.

Published in:

Nature Chemical Biology, 2013, v. 9, n. 12, p. 796, doi. 10.1038/nchembio.1361

By:

Zlitni, Soumaya;
Ferruccio, Lauren F;
Brown, Eric D

Publication type:

Article

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.

Published in:

Nature Chemical Biology, 2011, v. 7, n. 6, p. 348, doi. 10.1038/nchembio.559

By:

Ejim, Linda;
Farha, Maya A;
Falconer, Shannon B;
Wildenhain, Jan;
Coombes, Brian K;
Tyers, Mike;
Brown, Eric D;
Wright, Gerard D

Publication type:

Article

Antibiotics as probes of biological complexity.

Published in:

Nature Chemical Biology, 2011, v. 7, n. 7, p. 415, doi. 10.1038/nchembio.590

By:

Falconer, Shannon B.;
Czarny, Tomasz L.;
Brown, Eric D.

Publication type:

Article

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.

Published in:

Nature Chemical Biology, 2009, v. 5, n. 11, p. 849, doi. 10.1038/nchembio.221

By:

Pathania, Ranjana;
Zlitni, Soumaya;
Barker, Courtney;
Das, Rahul;
Gerritsma, David A.;
Lebert, Julie;
Awuah, Emilia;
Melacini, Giuseppe;
Capretta, Fred A.;
Brown, Eric D.

Publication type:

Article

Meropenem potentiation of aminoglycoside activity against Pseudomonas aeruginosa: involvement of the MexXY-OprM multidrug efflux system.

Published in:

2018

By:

Poole, Keith;
Gilmour, Christie;
Farha, Maya A.;
Parkins, Michael D.;
Klinoski, Rachael;
Brown, Eric D.

Publication type:

journal article

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08190-x

By:

Ellis, Michael J.;
Tsai, Caressa N.;
Johnson, Jarrod W.;
French, Shawn;
Elhenawy, Wael;
Porwollik, Steffen;
Andrews-Polymenis, Helene;
McClelland, Michael;
Magolan, Jakob;
Coombes, Brian K.;
Brown, Eric D.

Publication type:

Article

An Omniphobic Spray Coating Created from Hierarchical Structures Prevents the Contamination of High‐Touch Surfaces with Pathogens.

Published in:

Small, 2023, v. 19, n. 12, p. 1, doi. 10.1002/smll.202205761

By:

Abu Jarad, Noor;
Rachwalski, Kenneth;
Bayat, Fereshteh;
Khan, Shadman;
Shakeri, Amid;
MacLachlan, Roderick;
Villegas, Martin;
Brown, Eric D.;
Soleymani, Leyla;
Didar, Tohid F.

Publication type:

Article

Transparent and Highly Flexible Hierarchically Structured Polydimethylsiloxane Surfaces Suppress Bacterial Attachment and Thrombosis Under Static and Dynamic Conditions.

Published in:

Small, 2022, v. 18, p. 1, doi. 10.1002/smll.202108112

By:

Khan, Shadman;
Jarad, Noor Abu;
Ladouceur, Liane;
Rachwalski, Kenneth;
Bot, Veronica;
Shakeri, Amid;
Maclachlan, Roderick;
Sakib, Sadman;
Weitz, Jeffrey I.;
Brown, Eric D.;
Soleymani, Leyla;
Didar, Tohid F.

Publication type:

Article

Discovery of antibiotic adjuvants.

Published in:

Nature Biotechnology, 2013, v. 31, n. 2, p. 120, doi. 10.1038/nbt.2500

By:

Farha, Maya A;
Brown, Eric D

Publication type:

Article

An allosteric inhibitor of substrate recognition by the SCF<sup>Cdc4</sup> ubiquitin ligase.

Published in:

Nature Biotechnology, 2010, v. 28, n. 7, p. 733, doi. 10.1038/nbt.1646

By:

Orlicky, Stephen;
Xiaojing Tang;
Neduva, Victor;
Elowe, Nadine;
Brown, Eric D.;
Sicheri, Frank;
Tyers, Mike

Publication type:

Article

Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance.

Published in:

PLoS Pathogens, 2016, v. 12, n. 12, p. 1, doi. 10.1371/journal.ppat.1006067

By:

Sobhanifar, Solmaz;
Worrall, Liam J.;
King, Dustin T.;
Wasney, Gregory A.;
Baumann, Lars;
Gale, Robert T.;
Nosella, Michael;
Brown, Eric D.;
Withers, Stephen G.;
Strynadka, Natalie C. J.

Publication type:

Article