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- Title
CTXphi and Vibrio cholerae: exploring a newly recognized type of phage-host cell relationship.
- Authors
McLeod, Sarah M; Kimsey, Harvey H; Davis, Brigid M; Waldor, Matthew K
- Abstract
The genes encoding cholera toxin, one of the principal virulence factors of the diarrhoeal pathogen Vibrio cholerae, are part of the genome of CTXphi, a filamentous bacteriophage. Thus, CTXphi has played a critical role in the evolution of the pathogenicity of V. cholerae. Unlike the well-studied F pilus-specific filamentous coliphages, CTXphi integrates site-specifically into its host chromosome and forms stable lysogens. Here we focus on the CTXphi life cycle and, in particular, on recent studies of the mechanism of CTXphi integration and the factors that govern lysogeny. These and other processes illustrate the remarkable dependence of CTXphi on host-encoded factors.
- Publication
Molecular microbiology, 2005, Vol 57, Issue 2, p347
- ISSN
0950-382X
- Publication type
Journal Article
- DOI
10.1111/j.1365-2958.2005.04676.x