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- Title
A protein complex mediating mRNA degradation in Escherichia coli.
- Authors
Py, B; Causton, H; Mudd, E A; Higgins, C F
- Abstract
mRNA degradation in Escherichia coli is mediated by a combination of exo- and endoribonucleases. We present evidence for a multiprotein complex which includes at least two enzymes that play important roles in mRNA degradation: the exoribonuclease polynucleotide phosphorylase (PNPase) and the endoribonuclease RNase E. An activity which impedes the processive activity of PNPase at stem-loop structures also appears to be associated with the complex. This complex is estimated to have a molecular mass of about 500 kDa and includes several additional polypeptides whose functions are unknown. The identification of a complex which includes several activities associated with mRNA degradation has implications for the mechanisms and co-ordinated control of mRNA degradation.
- Publication
Molecular microbiology, 1994, Vol 14, Issue 4, p717
- ISSN
0950-382X
- Publication type
Journal Article
- DOI
10.1111/j.1365-2958.1994.tb01309.x