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- Title
A sequence-specific function for the N-terminal signal-like sequence of the TonB protein.
- Authors
Karlsson, M; Hannavy, K; Higgins, C F
- Abstract
TonB is a proline-rich protein which provides a functional link between the inner and outer membranes of Gram-negative bacteria. TonB is anchored to the inner membrane via an N-terminal signal-like sequence and spans the periplasm, interacting with transport receptors in the outer membrane. We have investigated the role of the N-terminal signal-like peptide in TonB function. Replacement of the N-terminal sequence with heterologous sequences indicates that it has at least three distinct roles in TonB function: (i) to facilitate translocation of TonB across the cytoplasmic membrane; (ii) to anchor TonB to the cytoplasmic membrane; (iii) a sequence-specific functional interaction with the ExbBD proteins.
- Publication
Molecular microbiology, 1993, Vol 8, Issue 2, p379
- ISSN
0950-382X
- Publication type
Journal Article
- DOI
10.1111/j.1365-2958.1993.tb01581.x