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- Title
Pharmacokinetics of total thyroxine in dogs after administration of an oral solution of levothyroxine sodium.
- Authors
Le Traon, G; Burgaud, S; Horspool, L J I
- Abstract
Oral L-thyroxine (L-T4) supplementation is used to replace thyroid hormone concentrations in dogs with hypothyroidism. The pharmacokinetics of L-T4 following administration of a solution (Leventa) was investigated in healthy dogs. L-T4 was absorbed fairly rapidly (t(max) 3 h). A mean bioavailability of 22% was calculated following a single oral administration of 40 microg L-T4/kg body weight. Repeated oral administration at the same dose for 14 consecutive days did not lead to any accumulation of T4 in serum. After intravenous administration of L-T4, a serum half-life of 11.6 h was calculated. Food intake concomitant with L-T4 oral administration delayed L-T4 absorption and decreased its rate and extent by about 45%. The relative bioavailability of L-T4 following administration of a tablet formulation was about 50% of that of the L-T4 solution. The pharmacokinetic properties of liquid L-T4 after oral administration support the use of a dose rate of 20 microg/kg once daily, as a starting dose for replacement therapy in dogs with hypothyroidism.
- Publication
Journal of veterinary pharmacology and therapeutics, 2008, Vol 31, Issue 2, p95
- ISSN
1365-2885
- Publication type
Journal Article
- DOI
10.1111/j.1365-2885.2007.00935.x