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- Title
Central apnoeas have significant effects on blood pressure and heart rate in children.
- Authors
O'Driscoll, Denise M; Foster, Alison M; Ng, Michelle L; Yang, Joel S C; Bashir, Farhat; Wong, Shi; Nixon, Gillian M; Davey, Margot J; Anderson, Vicki; Walker, Adrian M; Trinder, John; Horne, Rosemary S C
- Abstract
Brief central apnoeas (CAs) during sleep are common in children and are not usually considered clinically significant unless associated with oxygen desaturation. CAs can occur spontaneously or following a movement or sigh. The aim of this study was to investigate acute cardiovascular changes associated with CAs in children. Beat-by-beat mean arterial pressure (MAP) and heart rate (HR) were analysed across CAs, and spontaneous and movement-induced events were compared using two-way analysis of variance with post hoc analyses. Fifty-three children (28 male/25 female) aged 7-12 years referred for investigation of sleep-disordered breathing (SDB) and 21 age-matched healthy controls (8 male/13 female) were studied. Children underwent routine clinical polysomnography with continuous blood pressure (BP) recordings. Movement-induced, but not spontaneous, CAs were more frequent in children with mild or moderate/severe obstructive sleep apnoea (OSA) compared with healthy controls (P < 0.05 for both). Movement-induced CAs were associated with significantly larger MAP and HR changes across the event compared with spontaneous CAs. The percentage changes in MAP and HR between late-event and post-event were significantly greater for movement-induced compared with spontaneous CAs (MAP 20.6 +/- 2.3 versus 12.2 +/- 1.8%, P < 0.01; HR 28.2 +/- 2.6 versus 14.7 +/- 2.5%, P < 0.001). This study demonstrates that movement-induced CAs are more common in children with OSA, and are associated with significantly greater changes in HR and BP compared with spontaneous CAs. These data suggest that movement-induced CAs should be considered when assessing the cardiovascular impact of SDB.
- Publication
Journal of sleep research, 2009, Vol 18, Issue 4, p415
- ISSN
1365-2869
- Publication type
Journal Article
- DOI
10.1111/j.1365-2869.2009.00766.x