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- Title
Kisspeptins: regulators of metastasis and the hypothalamic-pituitary-gonadal axis.
- Authors
Murphy, K G
- Abstract
The kisspeptins are the peptide products of the KiSS-1 gene and the endogenous agonists for the GPR54 receptor. Although KiSS-1 was initially discovered as a metastasis suppressor gene, recent evidence suggests the kisspeptin/GPR54 system is a key regulator of the reproductive system. Disrupted GPR54 signalling causes hypogonadotrophic hypogonadism in rodents and man. Central or peripheral administration of kisspeptin potently stimulates the hypothalamic-pituitary-gonadal axis, increasing circulating gonadotrophin concentrations in a number of animal models. These effects appear likely to be mediated via the hypothalamic gonadotrophin-releasing hormone system, although kisspeptins may have direct effects on the anterior pituitary gland. Hypothalamic KiSS-1 expression is regulated by circulating sex steroids. The precise physiological role of the kisspeptin system in the regulation of reproductive function remains to be elucidated.
- Publication
Journal of neuroendocrinology, 2005, Vol 17, Issue 8, p519
- ISSN
0953-8194
- Publication type
Journal Article
- DOI
10.1111/j.1365-2826.2005.01328.x