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- Title
Plasma CD93 concentration is a potential novel biomarker for coronary artery disease.
- Authors
Mälarstig, A; Silveira, A; Wågsäter, D; Öhrvik, J; Bäcklund, A; Samnegård, A; Khademi, M; Hellenius, M-L; Leander, K; Olsson, T; Uhlén, M; de Faire, U; Eriksson, P; Hamsten, A
- Abstract
A common nonsynonymous single nucleotide polymorphism (SNP) in the CD93 gene (rs3746731, Pro541Ser) has been associated with risk of coronary artery disease (CAD). CD93 is a transmembrane glycoprotein, which is detectable in soluble form in human plasma. We investigated whether the concentration of soluble CD93 in plasma is related to risk of myocardial infarction (MI) and CAD, using a case-control study of premature MI (n = 764) and a nested case-control analysis of a longitudinal cohort study of 60-year-old subjects (analysis comprising 844 of 4232 subjects enrolled at baseline). In addition, SNPs in the CD93 gene were studied in relation to plasma CD93 concentration and CD93 mRNA expression.
- Publication
Journal of internal medicine, 2011, Vol 270, Issue 3, p229
- ISSN
1365-2796
- Publication type
Journal Article
- DOI
10.1111/j.1365-2796.2011.02364.x