We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mucosal T-cell responses to HIV: responding at the front lines.
- Authors
Shacklett, B L; Critchfield, J W; Ferre, A L; Hayes, T L
- Abstract
Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4(+) T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanisms, including secreted antibodies and CD8(+) cytotoxic T cells (CTL). CTL in mucosal lymphoid tissues may serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naïve host. This review summarizes recent literature on HIV-specific T-cell responses in mucosal tissues, with an emphasis on the gastrointestinal tract.
- Publication
Journal of internal medicine, 2009, Vol 265, Issue 1, p58
- ISSN
1365-2796
- Publication type
Journal Article
- DOI
10.1111/j.1365-2796.2008.02042.x