We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Self-injurious behaviour in intellectual disability syndromes: evidence for aberrant pain signalling as a contributing factor.
- Authors
Peebles, K A; Price, T J
- Abstract
In most individuals, injury results in activation of peripheral nociceptors (pain-sensing neurons of the peripheral nervous system) and amplification of central nervous system (CNS) pain pathways that serve as a disincentive to continue harmful behaviour; however, this may not be the case in some developmental disorders that cause intellectual disability (ID). Moreover, individuals affected by ID disorders may initiate self-injurious behaviour to address irritating or painful sensations. In normal individuals, a negative feedback loop decreases sensation of pain, which involves descending inhibitory neurons in the CNS that attenuate spinal nociceptive processing. If spinal nociceptive signalling is impaired in these developmental disorders, an exaggerated painful stimulus may be required in order to engage descending anti-nociceptive signals.
- Publication
Journal of intellectual disability research : JIDR, 2012, Vol 56, Issue 5, p441
- ISSN
1365-2788
- Publication type
Journal Article
- DOI
10.1111/j.1365-2788.2011.01484.x