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- Title
The effect of high dose of N-acetylcysteine in lupus nephritis: a case report and literature review.
- Authors
Tewthanom, K; Janwitayanujit, S; Totemchockcyakarn, K; Panomvana Na Ayudhya, D
- Abstract
An imbalance of oxidative-antioxidant defence mechanism has been proposed in systemic lupus erythematosus patients. Co-administration of N-acetylcysteine (NAC) which has a strong antioxidant activity may produce a satisfactory therapeutic outcome when added to standard therapy. We report a case of a 46-year-old lupus nephritis patient who received 1800 mg of NAC orally. After NAC, this patient showed a higher glutathione level, and a normal level of malondialdehyde, a lipid peroxidation product. In addition, the urinary protein levels, the complete blood counts and physical examination of the affected organs showed improvement. However, a well-controlled trial is needed to confirm the value of high-dose NAC in lupus nephritis patients.
- Publication
Journal of clinical pharmacy and therapeutics, 2010, Vol 35, Issue 4, p483
- ISSN
1365-2710
- Publication type
Journal Article
- DOI
10.1111/j.1365-2710.2009.01108.x