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- Title
Effects of claritromycin on inflammatory parameters and clinical conditions in children with bronchiectasis.
- Authors
Yalçın, E.; Kiper, N.; Özçelik, U.; Doǧru, D.; Fırat, P.; Şahin, A.; Arıyürek, M.; Mocan, G.; Gürcan, N.; Göçmen, A.
- Abstract
Background: The effects of the macrolides cannot be ascribed to their antibacterial action alone. Their immunoregulatory and anti-inflammatory functions are significant too. They are frequently used in the treatment of diffuse panbronchiolitis and cystic fibrosis (CF). Aim: To evaluate the effects of a macrolide antibiotic [clarithromycin (CAM)] on the process of inflammation [by measuring IL-8, TNF- α, IL-10 levels and cell profiles in bronchoalveolar lavage (BAL) fluid], pulmonary function and sputum production in children with steady-state bronchiectasis, secondary to causes other than CF or primary immunodeficiencies. Methods: Seventeen patients randomized to the treatment group received CAM and supportive therapies for 3 months and 17 patients in the control group were given supportive therapies only. Results: Compared with the control group, the treatment group showed a significant decrease in IL-8 levels, total cell count, neutrophil ratios in BAL fluid and daily sputum production at the end of the third month. There was also a significant increase in the treatment group's BAL fluid macrophage ratios. The differences in pulmonary function test parameters were not significant. Conclusion: Use of CAM in children with steady-state bronchiectasis results in laboratory improvement by reducing the inflammatory processes in the lungs. No corresponding clinical improvement could be shown but although this is possible with long-term use, trial validation is necessary.
- Publication
Journal of Clinical Pharmacy & Therapeutics, 2006, Vol 31, Issue 1, p49
- ISSN
0269-4727
- Publication type
Academic Journal
- DOI
10.1111/j.1365-2710.2006.00708.x