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- Title
The Gram-negative bacteria-binding protein gene family: its role in the innate immune system of anopheles gambiae and in anti-Plasmodium defence.
- Authors
Warr, E; Das, S; Dong, Y; Dimopoulos, G
- Abstract
Gram-negative bacteria-binding proteins (GNBPs) are pattern recognition receptors which contribute to the defensive response against Plasmodium infection in Anopheles. We have characterized the GNBP gene family in Anopheles gambiae at the molecular level, and show that they are functionally diverse components of the A. gambiae innate immune system. GNBPB4 is a major factor in the defence against a broad range of pathogens, while the other GNBPs have narrower defence specificities. GNBPB4 is associated with the regulation of immune signalling pathways and was found to interact with the Gram-negative Escherichia coli and weakly co-localized with Plasmodium berghei ookinetes in the mosquito midgut epithelium.
- Publication
Insect molecular biology, 2008, Vol 17, Issue 1, p39
- ISSN
1365-2583
- Publication type
Journal Article
- DOI
10.1111/j.1365-2583.2008.00778.x