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- Title
The companions: regulatory T cells and gene therapy.
- Authors
Eghtesad, Saman; Morel, Penelope A; Clemens, Paula R
- Abstract
Undesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial. In this article, we review relevant studies of immunological responses to gene replacement therapy, the role of immunological tolerance mediated by regulatory T cells in down-regulating the unwanted immune responses, and the interrelationship of the two topics.
- Publication
Immunology, 2009, Vol 127, Issue 1, p1
- ISSN
1365-2567
- Publication type
Journal Article
- DOI
10.1111/j.1365-2567.2009.03069.x