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- Title
Functional characterization of a T-cell receptor BV6<sup>+</sup> T-cell clone derived from a leprosy lesion.
- Authors
Sabet, Shereen; Ochoa, Maria-Teresa; Sieling, Peter A.; Rea, Thomas H.; Modlin, Robert L.
- Abstract
Human infection with Mycobacterium leprae, an intracellular bacterium, presents as a clinical and immunological spectrum; thus leprosy provides an opportunity to investigate mechanisms of T-cell responsiveness to a microbial pathogen. Analysis of the T-cell receptor (TCR) repertoire in leprosy lesions revealed that TCR BV6+ T cells containing a conserved CDR3 motif are over-represented in lesions from patients with the localized form of the disease. Here, we derived a T-cell clone from a leprosy lesion that expressed TCR BV6 and the conserved CDR3 sequence L-S-G. This T-cell clone produced a T helper type 1 cytokine pattern, directly lysed M. leprae-pulsed antigen-presenting cells by the granule exocytosis pathway, and expressed the antimicrobial protein granulysin. BV6+ T cells may therefore functionally contribute to the cell-mediated immune response against M. leprae.
- Publication
Immunology, 2007, Vol 120, Issue 3, p354
- ISSN
0019-2805
- Publication type
Academic Journal
- DOI
10.1111/j.1365-2567.2006.02510.x