We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Low frequency of MAP kinase pathway alterations in KIT and PDGFRA wild-type GISTs.
- Authors
Martinho, Olga; Gouveia, António; Viana-Pereira, Marta; Silva, Paula; Pimenta, Amadeu; Reis, Rui Manuel; Lopes, José Manuel
- Abstract
Gastrointestinal stromal tumours (GISTs) are commonly driven by oncogenic mutations in KIT and PDGFRA. However, 10-40% of these patients are wild-type for these genes. The prognostic significance of wild-type GISTs is controversial, and they rarely respond to imatinib. The aim of this study was to elucidate the molecular lesions underlying wild-type GISTs tumorigenesis.
- Publication
Histopathology, 2009, Vol 55, Issue 1, p53
- ISSN
1365-2559
- Publication type
Journal Article
- DOI
10.1111/j.1365-2559.2009.03323.x