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- Title
Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma.
- Authors
Frey, A B; Wali, A; Pass, H; Lonardo, F
- Abstract
Osteopontin (OPN) is a matricellular protein involved in tissue remodelling, cell-mediated immunity and malignant transformation. High OPN serum levels predict poor prognosis in non-small cell carcinoma and set patients with malignant pleural mesothelioma (MM) apart from disease-free asbestos-exposed individuals. Yet neither the spectrum of tissue expression nor the signalling pathways of OPN in MM and pulmonary adenocarcinoma have been characterized, although in vitro evidence links OPN to the epidermal growth factor receptor (EGFR) pathway. The aim of this study was to address these deficiencies.
- Publication
Histopathology, 2007, Vol 50, Issue 6, p720
- ISSN
0309-0167
- Publication type
Journal Article
- DOI
10.1111/j.1365-2559.2007.02675.x