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- Title
AQUA and FISH analysis of HER-2/neu expression and amplification in a small cell lung carcinoma tissue microarray.
- Authors
Giltnane, J M; Murren, J R; Rimm, D L; King, B L
- Abstract
Most small cell lung carcinoma (SCLC) patients have metastatic disease at the time of diagnosis and are faced with poor prognosis and limited treatment options. Reports of HER-2/neu gene amplification and overexpression in this malignancy have raised the possibility of applying targeted immunotherapy with trastuzumab, the monoclonal antibody used to treat metastatic breast cancer. However, a review of the studies measuring HER-2/neu gene amplification and protein expression in SCLC reveals discordant results. The aim of the present study was to re-examine HER-2/neu expression in SCLC in relation to gene copy number using the new, highly sensitive, immunofluorescence automated quantitative analysis (AQUA) technology.
- Publication
Histopathology, 2006, Vol 49, Issue 2, p161
- ISSN
0309-0167
- Publication type
Journal Article
- DOI
10.1111/j.1365-2559.2006.02479.x