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- Title
Different patterns of inflammation and prognosis in invasive carcinoma of the breast.
- Authors
Lee, A H S; Gillett, C E; Ryder, K; Fentiman, I S; Miles, D W; Millis, R R
- Abstract
Inflammation in carcinoma of the breast may represent an immune response to the tumour, but there is evidence that this response is impaired. Inflammation may also stimulate tumour growth by releasing proteolytic enzymes and angiogenic factors. Prognostic studies have produced conflicting results, but most investigators have not evaluated the different patterns of inflammation. The aim of this study was to test the hypothesis that moderate or marked diffuse inflammation is associated with a better prognosis. We also tested the 'danger model', which suggests that necrosis is necessary for an effective immune response.
- Publication
Histopathology, 2006, Vol 48, Issue 6, p692
- ISSN
0309-0167
- Publication type
Journal Article
- DOI
10.1111/j.1365-2559.2006.02410.x