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- Title
CD23 expression in mediastinal large B-cell lymphomas.
- Authors
Calaminici, M; Piper, K; Lee, A M; Norton, A J
- Abstract
Mediastinal large B-cell lymphoma (MLBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL) in the WHO classification with peculiar features, such as female prevalence, young patient age and bulky presentation. It shows a B-cell phenotype with variable expression of surface immunoglobulin, negative CD21 and CD10 and positive CD30 in a large number of cases. An origin from activated thymic B cells has been suggested in several studies. A subpopulation of large, dendritic cells (asteroid cells) strongly expressing CD23 has been identified amongst thymic B cells and these could represent the normal cellular counterpart for this type of primary mediastinal large cell lymphoma.
- Publication
Histopathology, 2004, Vol 45, Issue 6, p619
- ISSN
0309-0167
- Publication type
Journal Article
- DOI
10.1111/j.1365-2559.2004.01969.x