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- Title
53BP2 induces apoptosis through the mitochondrial death pathway.
- Authors
Kobayashi, Shinya; Kajino, Shinichi; Takahashi, Naoko; Kanazawa, Satoshi; Imai, Kenichi; Hibi, Yurina; Ohara, Hirotaka; Itoh, Makoto; Okamoto, Takashi
- Abstract
The p53 binding protein 2 (53BP2) has been identified as the interacting protein to p53, Bcl-2, and p65 subunit of nuclear factor kappaB (NF-kappaB). The TP53BP2 gene encodes two splicing variants, 53BP2S and 53BP2L, previously known as apoptosis stimulating protein 2 of p53 (ASPP2). We found that these 53BP2 proteins are located predominantly in the cytoplasm and induce apoptosis as demonstrated by cleavage of poly ADP ribose polymerase (PARP) and annexin V staining. Furthermore, we demonstrate that 53BP2 is located in the mitochondria and induces apoptosis associated with depression of the mitochondrial trans-membrane potential (DeltaPsim) and activation of caspase-9. From these findings we conclude that 53BP2 induces apoptosis through the mitochondrial death pathway.
- Publication
Genes to cells : devoted to molecular & cellular mechanisms, 2005, Vol 10, Issue 3, p253
- ISSN
1356-9597
- Publication type
Journal Article
- DOI
10.1111/j.1365-2443.2005.00835.x